ERBB3 anticorps

N° du produit ABIN238335

Cet anticorps anti-ERBB3 est un anticorps Souris Monoclonal détectant ERBB3 dans IHC et FACS. Adapté pour Humain.

Aperçu rapide pour ERBB3 anticorps (ABIN238335)

Antigène: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ERBB3 est non-conjugé

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: DY-7G2

Détail du produit anti-ERBB3 anticorps

Purification: Protein G

Immunogène: genetic immunisation with cDNA encoding human ErbB-3

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Commentaires:

Synonyms: Her3

Restrictions: For Research Use only

Stockage

Buffer: PBS, pH 7.2

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C

Stockage commentaire: short term: 2 °C - 8 °C, long term: -20 °C

Détails sur ERBB3

Antigène: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Autre désignation: ErbB3

Sujet: ErbB-3 belongs to the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB receptors (EGFR (ErbB1), ErbB2, ErbB3, and ErbB4) are important regulators of normal growth and differentiation, and they are involved in the pathogenesis of cancer. The 148-kDa trans-membrane polypeptide ErbB-3 has a neuregulin binding domain but not an active kinase domain. Heterodimerisation with EGF receptor family members which possess kinase activity leads to the activation of pathways which indicate cell proliferation or differentiation (1). Over-expression of ErbB-3 has been reported in numerous cancers, including prostate, bladder and breast tumours.

UniProt: P21860

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway